The development of efficient and versatile catalytic system for one-pot multicomponent reaction is one of the active ongoing research areas for further improvement towards milder reaction conditions. In this context, we report here in Boron trifluoride diethyl ether (BF3-Et2O) as a convenient and readily available catalyst for the synthesis of spirooxindole derivatives in satisfactory yields. This new protocol has the advantages of environmental friendliness, higher yields, shorter reaction times, low cost, and convenient operation.