The current study was designed to study acute oral toxicity study of Polyherbal formulation Ilavangath ichoornam according to OECD guidelines. Three albino rats wer e used for the study. Ilavangath ichoornam in five single oral doses was supplemented to all rats. The parameters like general appearance, behaviour, bodyweight, mor tality& necropsy were studied. No change in general appeara nce and mortality was observed. Ilavangath ichoorna m was found to be safe at dose of 2000mg/kg.