A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of fexofenadine from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.999 ) between 20 % to 100 % of 500 mg of drug substance weight. The percentage recovery of fexofenadine in the optimized method was between 99.739 to 101.724 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.