Intercultural communication competence reflects the comprehensive capacity for foreign language students to use language skills and professional knowledge，which is the mission and teaching goal for the English education．A post-CET4 college English teaching model based on intercultural communication was designed and applied in English teaching in sophomore students of clinical medicine science major. The students were divided into experimental group and control group. Conventional teaching model was adopted for the control group, while the new model was applied for the experimental group for one academic year. According to experimental statistics, it is shown that the experimental group presents some advantages in English learning ability and confidence in communication. The post-CET4 English teaching model has a significant effect on the intercultural communication competence with scores in the middle and lower levels and it is expected to be promoted throughout the whole university.