Traditional plants are the potential sources of many potent and powerful drugs. They represent a rich source of antimicrobial and anthelmintic activity. The development of resistance and high cost of conventional synthetic drugs have paved the way to the evaluation of alternative source of medicines. The present study was undertaken to evaluate antimicrobial and anthelmintic activity of methanolic extract of leaves of Syzygium malaccense (L.) Merr. & Perry. Antimicrobial activity was evaluated against clinically important Proteus bacteria and Candida albicans using Kirby-Bauer disk diffusion method. The result showed that extract have moderate degree of both antibacterial and antifungal activity. The anthelmintic activity was carried as per method of Ajaiyeoba et al, which involves determination of time of paralysis and time of death of earthworm (Pheretima posthuma). The result showed that extract, revealed a concentration dependent anthelmintic activity.