Irrational use of antibiotics can cause increase adverse drug reaction, lead to antibiotic resistance and increase the treatment cost. Assessment of pattern of antibiotics utilization is significant in the context of its increase use and its overall impact on the health care system. The present study was a prospective study done in general medicine ward of a tertiary care teaching hospital to analyze the utilization pattern of antibiotics.200 patients were included in the study. Most common cause of antibiotics intake was respiratory tract infection. Most common antibiotic used was ceftriaxone.Number of antibiotics prescribed per prescription were 1.83.Antibiotics were mostly prescribed by brand name.As antibiotics are most commonly prescribed drugs and report of misuse is not uncommon so proper strategy like educational intervention and antibiotic policy are necessary to control this.