The study intends to evaluate the effectiveness of life review with Islamic ontological orientation on the parent-child relationships in adolescent. For this purpose, two families, who were in conflict with their adolescents and consented to participate in the study, were selected out of clients of counseling centers using available sampling method. The model of life review treatment with Islamic ontological orientation proposed by Ismaeeli (2010) was implemented for this group in six 90 minute sessions. In this study, qualitative data was collected using interviews and open-ended questions designed under the supervision of relevant experts in this field. Since the research method is qualitative (case study), the single-subject design (baseline step after the follow-up treatment) was adopted. The qualitative data were respectively analyzed by descriptive phenomenological method. The results showed that life review therapy with Islamic ontological orientation could effectively reduce conflicts in parent - child relationships (e.g. by changing the view of parents - children toward the universe, God and other humans and their mutual empathy, understanding and acceptance), thus improving their relationship significantly.