Introduction: mental health in the society is one of the pivots for assessment of health in different societies. According to studies mental disorders are one of the main and most significant parts of the total burden of diseases and it is predicted that mental and neurological disorders’ share of total burden of diseases is increased 50 percent by 2020 and reaches 15 percent, up from the present 10.5 percent. This study is a descriptive-analytical study that was conducted in winter 2014. The population of the study is consisted of 423 employees of health sector in the Kohkiloye County which entered the study using census method. The data were collected using the standard General Health Questionnaire-28 (GHQ-28) and were analyzed by SPSS using descriptive and inferential statistics. The samples were consisted of 236 males and 187 females. Significant relationships were found between sex and general health (P<0.001), between marital status and general health (P<0.021), between education level and general health (P<0.002), between work experience and general health (P<0.02) and between workplace and general health (P<0.02). However, no significant relationship of occupation, age and monthly income with general health was found. The findings of this study indicated that mental disorders are prevalent in the employees of the health sector in Kohkiloye County to an average extent. Therefore, authorities should pay attention to mental health in these individuals and improve their general health status by creating interventional programs.