As quality is the most important aspect of any manufacturing process, it becomes necessary to validate or examine all the peripherals connected to the manufacturing instruments used in pharmaceutical industries. Among all the peripherals connected to the manufacturing instruments, computer is the main equipment, as it controls and handles all the activities of manufacturing process starting from input to finalized output. This article explains validation processes of any computer systems to avoid any risk to product identity, purity, strength and efficacy by providing consistent and secure operation and reducing the potential of human error.