Solanum trilobatum is one of the medicinal plants commonly available in different parts of the world and this plant is used in Indian system of medicine to cure various diseases in human and animals. Phytochemical screening of this plant extract proved the presence of major bioactive drugs such as sobatum, solasodine, tomatidine, disogenin and solaine in various parts of the plant including leaf, stem, root, flowers and berries to treat various diseases like tuberculosis, respiratory problems and bronchial asthma. Bioactive compounds have been tested for anti-microbial, anti-inflammatory, antioxidant, cytotoxic, anti-diabetic and immunomodulatory activities. We have reviewed the selected bioactive compounds and phytochemicals from Solanum trilobatum in treating a tumor, cancer cells, and other diseases also involve in upsurge the immunity.