A simple, precise, accurate, reproducible, economical and sensitive reverse phase liquid chromatography method was developed and validated for the simultaneous estimation of Domperidone and Pantoprazole in bulk and marketed formulations. Evaluation of drugs in this combination was performed with a C18 column [ Kromasil column. 250mm × 4.5 mm] using mobile phase of composition Acetonitrile and phosphate buffer (60:40 v/v, pH 7).The flow rate was 0.8 ml/min, and the effluents were monitored at 288nm. The retention time of Domperidone and Pantoprazole were 3.46 min and 5.34 min respectively. The method was found to be linear over a range of 10-50 mg/ml for Domperidone and 40-200mg/ml for Pantoprazole. The established method proved as reproducible one with a %RSD value of less than 2 and having the robustness and accuracy within the specified limits. Assay of marketed formulation was determined and find with 99.08% and 99.87% for Domperidone and Pantoprazole respectively. The method was validated according to the guidelines of International Conference on Harmonization (ICH) and was successfully employed in the estimation of commercial formulations. This liquid chromatographic method can be applied for the qualitative and quantitative determination of selected drugs by the modern chemist