The acute toxicity (LD50) of insecticides carbofuran and its effects on male reproduction in rats were carried out. Carbofuran was given orally to dose (2.4 mg kg-1 b.wt, corresponding to 1/25 LD50) alone and in combination with date palm pollen grains extracts (60 mg/ kgb.wt) and vanadylfolate (50 mg /kg b.wt). Fertility index, weight of sexual organs, semen picture, serum testosterone level and activity of lactate dehydrogenase (LDH), acid phosphatase enzymes and fructose content in serum. Results showed that there was a correlation between carbofuran administration and the significant decrease of the fertility index, weight of the testes and accessory male sexual glands, serum testosterone level and sperm cell abnormality. Carbofuran increased significantly lactate dehydrogenase and acid phosphate activity and decreased the fructose content in the serum. In contrast Coadministration of date palm pollen grains or vanadylfolate to carbofuran treated rats restored almost of these biochemical parameters to normal levels and alleviates the toxic effects of carbofuran on reproductive functions in male rats.