Angiogenesis means the growth of new capillary blood vessels in the body is an important natural process used for healing and reproduction. The body controls angiogenesis by producing a precise balance of growth and inhibitory factors in healthy tissues. When this balance is disturbed, the result is either too much or too little angiogenesis. Excessive angiogenesis occurs in diseases such as cancer, diabetic blindness, age-related macular degeneration, rheumatoid arthritis, psoriasis, and more than 70 other conditions for these Anti angiogenic therapies are aimed to halt new blood vessel growth there by using angiogenesis inhibitors have been also discovered from natural sources to treat cancer. Insufficient angiogenesis occurs in diseases such as coronary artery disease, stroke, and chronic wounds. Therapeutic angiogenesis aimed to stimulate new blood vessel growth with growth factors is being developed to treat these conditions. Angiogenic gene therapy is also being developed as a method to deliver angiogenic growth factors to the heart, limbs, and wounds. Currently there is no angiogenic gene therapy and drugs approved by FDA for the treatment of ischemic cardiovascular disease. But FDA approved device is used to stimulate NBV to grow in diseased hearts is a laser used in a technique called Direct Myocardial Revascularization. The present review will helpful for the discovery of potent angiogenesis growth factors and further research findings from various sources is to be encouraged to alternate the recombinant protein, monoclonal antibody, device and cell based therapies