The discovery of fullerene in 1985 opened the door to a wide area of study. Fullerenes have been used in a variety of fields because of their cage-like structure, high reactivity, and ease of substitution and complexation with different metals. The formation of adducts with different types of metal and compound bulky ball of carbons has a wide range of therapeutic applications. Their application explore from diagnosis to treatment. After modification, these bulky balls can be used as an anti-oxidant, anti-microbial, anti-HIV, anti-tumor, neuroprotective and antiviral agent.