In this aid we describe the preparation, loading and sustained release of SBA-15-Ketoconazole composite. Silica-based ordered mesoporous material (SMM) called SBA-15 is synthesized and loaded with ketoconazole by incipient wetness method and characterized by UV-visible spectrophotometer and small angle powder X-ray diffraction (PXRD. The successful invading of Ketoconazole in host material SBA-15 was confirmed by UV-visible spectrophotometer with high encapsulation efficiency 72.67% in the composite material. The controlled release effect of the Ketoconazole drug in fluid was studied by examining the drug release profile of composite into simulated gastric fluid. The composite showed sustained released with higuchi model. So, this high loaded silica based composite are used as a womb for sustained delivery of Ketoconazole drug to in order to improve the release of ketoconazole in its preferential absorption region.