Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Synthesis of Spiro[4H-pyran-3,3-oxindole] by 1,3-Dibromo-5,5-dimethyl hydantoin(DBDMH) As a Catalyst Using Eco-Friendly Medias

Author(s): Yasamin Saadati, Seyedeh F Hojati, Maan Al Naddaf and Mohammad Keshe

A highly efficient method for the synthesis of unsymmetrical spiro[4H-pyran-3,3-oxindole] is reported by three-component condensation of isatin, malonitrile and dimedone in the presence of catalytic amount of 1,3-dibromo-5,5-dimethyl hydantoin (DBDMH); High yields of products, short reaction times the use of non-toxic solvent and easy work-up in combination with commercial availability, low cost and non-toxicity of the catalyst make this work eco-friendly and commercially acceptable.

PDF