Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Synthesis, biological and pharmacological activities of 2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazoles

Author(s): M. S. Chaitanya, G. Nagendrappaand V. P. Vaidya

Anilines 1a-h on reaction with potassium thiocyanate and bromine in acetic acid yielded substituted 2-amino[2,1-b][1,3]benzothiazoles 3a-h . The compounds 3a-h on reaction with ethyl acetoacetate and pheylidine acetoacetate , yielded, 2-methyl-4-H-pyrimido[2,1- b][1,3]benzothiazole-4-ones 4a-h and ethyl 4-phenyl-2-methyl-4H–pyrimido[2,1- b][1,3]benzothiazole-3-carboxylates 5a-h respectively. Pheylidine acetoacetate was conveniently prepared by employing Knoevnagel metho d using diethyl amine as catalyst. The newly synthesized compounds have been characterized by analytical data IR, 1 H NMR, 13 C NMR and mass spectral data. The compounds were then eva luated for antibacterial, antifungal, and anti-inflammatory activities.

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