Synthesis and Characterization of Impurity G of Risperidone: An Antipsychotic Drug

Vascuri Janardhana Rao; Rama Shankar; Khagga Mukkanti; N.A. Vekariya

Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Synthesis and Characterization of Impurity G of Risperidone: An Antipsychotic Drug

Author(s): Vascuri Janardhana Rao, Rama Shankar, Khagga Mukkanti and N.A. Vekariya

The Metabolite and European pharmacopoeia impurity G of Risperidone, chemically known as 3-[2-[4-(4-fluoro-2- hydroxybenzoyl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido -[1,2-a]pyrimidin-4-one (2, Risperidone hydroxy keto analogue), preparation and its structural confirmation by spectral analysis data have been described.

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