A green and efficient hydrolysis of methyl 5-chloropyrazine-2-carboxylate to 5-chloro- pyrazine-2-carboxylic acid

Hong-Qiang Hea; Yu-Wei Changb; Wei-Ming Xub; Fang-Ming Liuab

Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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A green and efficient hydrolysis of methyl 5-chloropyrazine-2-carboxylate to 5-chloro- pyrazine-2-carboxylic acid

Author(s): Hong-Qiang Hea, Yu-Wei Changb, Wei-Ming Xub and Fang-Ming Liuab

an efficient and green procedure for the preparation of 5-chloropyrazine- 2-carboxylic acid from methyl 5-chloropyrazine-2-carboxylic acid ester using LiOH with the evident advantages of very easy operations, environmentally benign conditions and high yield of the product. It is a very green and easy transformation for no organic solvents were used during the whole reaction and separation procedure to obtain the high yield

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